Members of the nuclear receptor superfamily of transcription factors have important roles in modulating the responses of macrophages, microglia and lymphocytes to pro-inflammatory signalling ...
You have full access to this article via your institution. The sequence homology across the nuclear receptor superfamily indicates that these receptors evolved through divergent evolution 5 ...
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FXR cyclic peptide antagonists as a novel strategy for MASH treatmentIn this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...
A team led by researchers at the University of Toronto has discovered that a compound present in ginger selectively binds to and regulates a nuclear ...
More information: Xiaojuan Wang et al, An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice, Nature Communications (2025). DOI: 10. ...
Top-Line Data from Phase 2 CALLIPER Trial of Vidofludimus Calcium in Progressive Multiple Sclerosis Expected in April – NEW YORK, Feb. /PRNewswire/ -- Immunic, Inc.
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