Professor Hirohide Saito and his research team have developed a new microRNA-responsive hybrid mRNA switch, enabling precise, ...

Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

Results. We identified six differentially expressed circRNAs in HCC, which were linked to 13 miRNAs and 88 mRNAs. A network containing 34 circRNA-miRNA pairs and 194 miRNA-mRNA pairs was constructed.

For example, they have characterized the transcriptome (mRNA, lncRNA, and miRNA) of aortas in an atherosclerosis mouse model, both during disease progression and after regression following treatment.

When miRNA acts as the guide for RNAi, only a short part of the molecule, known as the seed region, pairs with the target, rather than the full ~20 nucleotide sequence. 1 This means miRNA guides can ...

This miRNA-mRNA pairing is generally entirely complementary in plants but only partially complementary in animal cells. In most instances, miRNA suppresses mRNA expression by binding to the 3′ ...

As diseases, including cancers, progress, changes in microRNA expression levels are observed. Specifically, in prostate cancer, the number of miR-93-5p microRNAs increases, and higher levels of ...

We identified twelve novel saliva and serum miRNAs and a panel of unique miRNA and mRNA signatures, significantly differentially expressed in saliva and serum of OSCC patients versus HC ...

Once the miRNA binds to its target, the target mRNA is either marked for destruction or is unable to serve as a template to produce protein, thus switching protein production off.

We now know that humans have more than 1,000 types of microRNA and that virtually every gene is regulated at the mRNA level by several microRNAs. Related Nobel Prize in chemistry goes to CRISPR ...

In addition, a section in lin-14 mRNA was discovered to be necessary for inhibition by lin-4. The two laureates compared their results, leading to a groundbreaking discovery.

The 2024 Nobel Prize in Physiology or Medicine was jointly awarded to Victor R. Ambros, PhD, and Gary Ruvkun, PhD, for the discovery of microRNA and its role in gene regulation.The Nobel Assembly ...