Leukocyte Adhesion Deficiency Type I (LAD-I) is an extremely rare genetic disease, occurring in one case per million, caused ...

An investigational gene therapy has successfully restored immune function in all nine children treated with the rare and life-threatening immune disorder called severe leukocyte adhesion deficiency-I, ...

Three American siblings and six other children born with a rare, life-threatening disease are returning to normal life thanks ...

Their rare genetic condition, severe leukocyte adhesion deficiency-I, or LAD-I, is caused by mutations in a gene that supports healthy immune system function — without it, affected individuals are at ...

The β 2 common integrin subunit CD18 is essential for leukocyte–endothelial adhesion and extravasation to inflamed or infected tissue. Damaging variants in ITGB2, which encodes CD18 ...

During rolling, leukocytes receive signals from the inflamed vessel wall, which induce a further slowing down and eventual firm arrest (adhesion) of the leukocyte to the vessel wall. Firm ...

Eisa Hussain was born with the rare condition leukocyte adhesion deficiency 1 (LAD-1) which means his body could not fight off infections and would have been a “death sentence” that would have ...

A boy with an ultra-rare immune disease which can carry a "death sentence" is starting to live a normal life after taking part in a groundbreaking gene therapy trial. Eisa, from Reading, now enjoys ...

Eisa Hussain, who suffers from a severe form of leukocyte adhesion deficiency 1 (LAD-1), can now play football and attend school – milestones his family once thought impossible. LAD-1 cripples ...

An investigational gene therapy has successfully restored immune function in all nine children treated with the rare and life-threatening immune disorder called severe leukocyte adhesion ...

An investigational gene therapy has successfully restored immune function in all nine children treated with the rare and life-threatening immune disorder called severe leukocyte adhesion ...

The central nervous system (CNS) has been characterized as an immunologically privileged site in the past, but it should more accurately be viewed as immunologically specialized. It is probable ...