Andrew Kuykendall, MD, discusses data from a phase 2 trial of fedratinib for the treatment of myeloproliferative neoplasms.

(A) Experimental validation of NP rat model by detecting PWT and NSF. (B) The expression levels of IL-6, TNF-α, and IL-1β were detected by ELISA in respective groups. (C) The counts of peak ...

The study suggests that disturbances in the JAK-STAT signaling pathway, an important communication pathway in the body, may contribute to this side effect. "In the study, we uncover the potential ...

Panelists discuss how investigational therapies beyond Janus kinase (JAK) inhibition, including epigenetic modulation, telomerase inhibition, PI3K/AKT/mTOR pathway inhibition, immune modulation, TGF-β ...

Fast Five Quiz: The JAK-STAT Pathway and Atopic Dermatitis Do you know the nuances between the JAK-STAT pathway and atopic dermatitis? Check your knowledge with this quick quiz.

A recent study published by the lab in Nature Communications [2024; PMID: 38355560] sheds light on this aspect by elucidating the role of the IL6/JAK/STAT3 signaling pathway in driving bladder cancer ...

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