This new article publication from Acta Pharmaceutica Sinica B, discusses how a CMD-OPT model enables the discovery of a ...

Background: Phosphoribosylation of 5-FU is an essential step leads to tumor growth inhibition and OPRT is the main enzyme that involves in this conversion of 5-FU to FUMP. We have reported the ...

Background: Dihydropyrimidine dehydrogenase and thymidylate synthase are 5-FU metabolism and target enzyme, and has been studied as prognostic factors in CRC. Meanwhile, phosphoribosylation of 5-FU is ...