The Scientist5d
Mapping the Shift from Healthy Stem Cells to Oral Cancer
Single-cell analysis revealed the molecular triggers that drive stem cells to become cancerous, which may help inform ...
Nature7mon
How size is controlled: from Hippos to Yorkies
Phosphorylation of this site by the mammalian Hippo pathway is also observed in the mammalian Yki homologue YAP at Ser127 and is followed by YAP shuttling out of the nucleus, which provides an ...
Hosted on MSN7mon
Review highlights the interplay of TGF-β and HIPPO pathways in liver regeneration and disease
The HIPPO pathway controls organ size by regulating cell proliferation and apoptosis, acting through its core components MST1/2, LATS1/2, and downstream effectors YAP and TAZ. In the liver ...
AZoLifeSciences on MSN6d
Investigating Ubiquitination's Role in Cancer Stem Cell Regulation
This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), ...