The CV benefit of statins can be partly explained by their ability to inhibit of HMG-CoA reductase, which subsequently lowers cholesterol and decreases the formation of mevalonate. However ...

18 Anti–HMG-CoA reductase autoantibodies may also be present in patients with autoimmune myopathy who have never been prescribed statin therapy. 8,10,17,23 Such patients, who made up one third ...

HMG-CoA reductase inhibitors, commonly referred to as statins, are the cornerstone of pharmacologic reduction of elevated low-density lipoprotein cholesterol. LDL-C is the main contributor to ...

Figure 1: Atorvastatin treatment inhibits or reverses chronic and relapsing EAE. Figure 3: Atorvastatin inhibits T-cell proliferation and promotes a Th2 response. Figure 4: Atorvastatin has ...

HMG-CoA reductase inhibitors such as atorvastatin and rosuvastatin are more potent than older statins. They have half-lives of at least 14 hours. Extended-release fluvastatin, or Lescol XL ...

This is certainly the case for the use of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors — statins — and the risk of new-onset diabetes. Cardiovascular disease is the ...

Statin drugs work by preventing our body from making as much cholesterol as we otherwise would by blocking an enzyme called HMG-CoA reductase. A drug in a different class called ezetimibe works by ...